Intra-Articular Injections With Carboxymethyl-Chitosan In Patients Pretended By Knee Osteoarthritis Non-Responders To Hyaluronic Acid : A Pilot Study

Osteoarthritis ( OA ) is a disabling disease that stimulates pain and functional limitation . OA symptoms can be treated with intra-articular injections of anti-inflammatory , viscosupplementary , or viscoinductive products . Non-responders to these approaches have restricted options , oft surgical ( e.g . knee substitution ) . This retrospective work aims to judge the efficacy of a undivided injection of Carboxymethyl-Chitosan for modern ( Kellgren-Lawrence ≥3 ) and symptomatic knee OA in non-responders to hyaluronic acid .

We recruited 10 patients ( 5 female , 5 male ) . Treatment efficacy was assessed through the Visual Analogue Scale ( VAS , pain ) and the Knee trauma and Osteoarthritis Outcome grade ( KOOS , knee function ) . Data are acquired from paygrade scales were alloted at the time of injection ( T0 ) , one month ( T1 ) , three months ( T2 ) , and six months ( T3 ) after treatment as for clinical practice . Results demoed a meaning improvement in pain and map at T1 , with a subsequent gradual recommencement of symptoms . In closing , the discourse pictured a sound outcome in the inadequate term ( i.e . up to 1 month after treatment ) ; however , raw values of VAS and KOOS did not return to baseline storys reading a care of advance albeit not statistically significant .

Development of Interpolyelectrolyte Complex based on Chitosan and Carboxymethylcellulose for Stabilizing Sandy Soil and Stimulating flora of Scots Pine ( Pinus sylvestris L. ) .The issue of piss and wind corrosion of soil stays critically important . Polymeric cloths tender a hopeful answer to this problem . In  Seebio Amino Acids  , we prepared and applied an interpolyelectrolyte complex ( IPEC ) indited of the biopolymers chitosan and sodium carboxymethyl cellulose ( Na-CMC ) for the structuring of forest sandy grunges and the sweetening of the pre-sowing treatment of Scotsman pine ( Pinus sylvestris L. ) seeds . A nonstoichiometric IPEC [ Chitosan ] : [ Na-CMC ] = [ 3:7 ] was synthesized , and its composition was determined practicing hydrometry , turbidimetry , and rheoviscosimetry methods .

Soil surface discussion with IPEC involved the sequent application of a chitosan polycation ( 0 % w/w ) and Na-CMC polyanion ( 0 % w/w ) relative to the air-dry soil weight . The prepared IPEC increased soil wet by 77 % , lengthy piss holding time by sixfold , replicated the contentedness of agronomically valuable soil fractions > 0 mm , enhanced soil resistance to water erosion by 64 % and wind erosion by 81 % , and improved the mechanical posture of the soil-polymer incrustation by 17 times IPEC application leaded in svelte gains in the substance of humus , mobile potassium , peregrine phosphorus , ammonium N , and mineral SALTs in the soil while defending soil solvent pH stability and significantly increasing nitrate N points . The novel application technologies of biopolymers and IPEC led to a 16-25 % improvement in Scot pine seed sprouting and seedling growth metrics.Enhanced Antioxidant , Anti-Aging , Anti-Tyrosinase , and Anti-Inflammatory belongings of Vanda coerulea Griff . Ex Lindl . Protocorm through elicitation with Chitosan.This study aimed to enquire the effects of elicitors on Vanda coerulea Griff .

Amino Acids  . protocorms to raise bioactive compound output and evaluate their biologic activities relevant to cosmeceutical coverings . The protocorms were prepared from the callosity handled with unlike elicitors , admiting 6-benzylaminopurine ( BA ) , methyl jasmonate ( MeJA ) , and chitosan . Both the adult flora and protocorms were extracted by boniness in 80 % methanol and inquired for their chemical compositions using high-performance liquidness chromatography . The selections were evaluated for antioxidant , anti-collagenase , anti-elastase , and anti-tyrosinase actions . In plus , anti-inflammatory properties were appraised employing a real-time polymerase chain reaction . The discomfort authority was judged using the hen 's egg test-chorioallantoic membrane test .

The determinations revealed that protocorms plowed with BA and chitosan developed a greener color , while those treated with MeJA demonstrated a distinct darker colour .